Neuro 02
نویسندگان
چکیده
Objective: To analyze the usefulness of determining the cerebrospinal fluid(CSF) levels of tumor necrosis factor-α(TNF-α),interleukin-1β(IL-1β) and interleukin-6(IL-6)for the early diagnosis and evaluation of the prognosis of neonatal meningitis. Method: We studied 54 newborn that underwent lumbar puncture.Thirty patients had meningitis and 24 were the control group.CSF and sera were obtained at the moment of suspicion of meningitis and stored at -700C.Cytokines were performed by enzyme-linked immunosorbent assay method. Results: CSF cytokines were detected in all the newborn with meningitis.TNF-α was detected in the CSF in 63.3% of the neonates, IL-1β in 73.3% and IL-6 in 96.6%.The CSF levels were significantly higher than serum in neonates with meningitis.There was no correlation between the CSF levels of cytokines and neurologic complications. Conclusion: The detection of TNF-α, IL-1β and IL-6 in the CSF is of great value in order to achieve a early diagnosis of neonatal meningitis.Among the three cytokines analyzed, IL-6 was the best indicator of meningeal inflammation.
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